// DNA Mathematical Architecture: G¹⁶ Helix System // 44 Bonds — 10.6 Periodicity — Complete Implementation #pragma once #include #include #include #include #include #include namespace agi::dna { // ============================================================================ // I. FOUNDATIONAL CONSTANTS // ============================================================================ // Golden ratio and derived constants constexpr double PHI = 1.6180339887498948482; // (1 + √5) / 2 constexpr double PHI_INV = 0.6180339887498948482; // 1 / φ = φ - 1 // DNA Helix parameters constexpr double BASE_PAIRS_PER_TURN = 10.6; // p = 10.6 bp constexpr double HELIX_RADIUS = 1.0; // r = 1.0 nm constexpr double RISE_PER_BP = 0.34; // h = 0.34 nm constexpr double PITCH = RISE_PER_BP * BASE_PAIRS_PER_TURN; // P = 3.604 nm constexpr double TWIST_ANGLE_DEG = 360.0 / BASE_PAIRS_PER_TURN; // 33.96° constexpr double TWIST_ANGLE_RAD = 2.0 * M_PI / BASE_PAIRS_PER_TURN; // 0.593 rad constexpr double ANGULAR_FREQUENCY = TWIST_ANGLE_RAD; // ω = 0.593 rad/bp // Strand parameters constexpr int NUM_STRANDS = 16; constexpr double STRAND_SEPARATION = 2.0 * M_PI / NUM_STRANDS; // 22.5° constexpr int NODES_PER_STRAND = 312; constexpr int TOTAL_NODES = 5000; constexpr int HUB_NODES = 8; // Olympus routing nodes // Bond parameters constexpr int INTRA_STRAND_BONDS = 16; constexpr int INTER_STRAND_BONDS = 16; constexpr int CROSS_HELIX_BONDS = 12; constexpr int TOTAL_BONDS = 44; // Curvature and torsion (pre-computed) constexpr double HELIX_CURVATURE = 0.745; // κ = 0.745 nm⁻¹ constexpr double HELIX_TORSION = 0.427; // τ = 0.427 nm⁻¹ // Synchronization constexpr double SYNC_PERIOD = BASE_PAIRS_PER_TURN * NUM_STRANDS; // 169.6 time units constexpr double FUNDAMENTAL_FREQ = 1.0 / BASE_PAIRS_PER_TURN; // 0.0943 cycles/bp constexpr double BOND_RESONANCE_FREQ = TOTAL_BONDS / BASE_PAIRS_PER_TURN; // 4.15 cycles/turn // Steady state constexpr double STEADY_STATE_BONDS = 36.2; constexpr double BOND_OCCUPATION = 0.82; constexpr double TAU_SLOW = 10.0; // ms constexpr double TAU_FAST = 0.0001; // ms (0.1 μs) // ============================================================================ // II. G¹⁶ PARAMETRIC HELIX // ============================================================================ struct HelixPoint { double x, y, z; HelixPoint operator+(const HelixPoint& other) const { return {x + other.x, y + other.y, z + other.z}; } HelixPoint operator-(const HelixPoint& other) const { return {x - other.x, y - other.y, z - other.z}; } HelixPoint operator*(double s) const { return {x * s, y * s, z * s}; } double norm() const { return std::sqrt(x*x + y*y + z*z); } double dot(const HelixPoint& other) const { return x*other.x + y*other.y + z*other.z; } }; // G¹⁶ Parametric Helix equations (Section 1.1) // x_k(θ) = r·cos(θ + 2πk/16) // y_k(θ) = r·sin(θ + 2πk/16) // z_k(θ) = (p/2π)·θ + δ_k class G16Helix { public: // Vertical offset per strand: δ_k = k·h/16 static double vertical_offset(int k) { return k * RISE_PER_BP / NUM_STRANDS; } // Golden phase offset: θ_k = 2πk·φ⁻¹ mod 2π static double golden_phase_offset(int k) { return std::fmod(2.0 * M_PI * k * PHI_INV, 2.0 * M_PI); } // Get point on strand k at parameter θ static HelixPoint point(int k, double theta) { double phase = theta + 2.0 * M_PI * k / NUM_STRANDS; return { HELIX_RADIUS * std::cos(phase), HELIX_RADIUS * std::sin(phase), (PITCH / (2.0 * M_PI)) * theta + vertical_offset(k) }; } // Get point with golden ratio phase adjustment static HelixPoint point_golden(int k, double theta) { double phase = theta + golden_phase_offset(k); return { HELIX_RADIUS * std::cos(phase), HELIX_RADIUS * std::sin(phase), (PITCH / (2.0 * M_PI)) * theta + vertical_offset(k) }; } // Curvature at point (Section 1.3) // κ = r/(r² + (p·h/2π)²) static double curvature() { double ph_term = PITCH * RISE_PER_BP / (2.0 * M_PI); return HELIX_RADIUS / (HELIX_RADIUS * HELIX_RADIUS + ph_term * ph_term); } // Torsion at point (Section 1.3) // τ = (p·h/2π)/(r² + (p·h/2π)²) static double torsion() { double ph_term = PITCH * RISE_PER_BP / (2.0 * M_PI); return ph_term / (HELIX_RADIUS * HELIX_RADIUS + ph_term * ph_term); } // Stability metric: exp(-Σ|τ(n)|·φ⁻ⁿ) static double stability_metric(const std::vector& torsions) { double sum = 0.0; double phi_power = 1.0; for (size_t n = 0; n < torsions.size(); ++n) { sum += std::abs(torsions[n]) * phi_power; phi_power *= PHI_INV; } return std::exp(-sum); } // Helix balance: Σκ(n)·φ⁻ⁿ static double helix_balance(const std::vector& curvatures) { double sum = 0.0; double phi_power = 1.0; for (size_t n = 0; n < curvatures.size(); ++n) { sum += curvatures[n] * phi_power; phi_power *= PHI_INV; } return sum; } // G¹⁶ Mean curvature: (1/16) Σ κ_k × cos(2πk/10.6) static double mean_curvature_g16() { double sum = 0.0; double kappa = curvature(); for (int k = 1; k <= NUM_STRANDS; ++k) { sum += kappa * std::cos(2.0 * M_PI * k / BASE_PAIRS_PER_TURN); } return sum / NUM_STRANDS; } // Full rotation calculation // θ_total = 16 × (2π/10.6) = 9.49 rad = 543.8° static double total_rotation() { return NUM_STRANDS * TWIST_ANGLE_RAD; } // Turns per 16 strands = 1.51 static double turns_per_16_strands() { return total_rotation() / (2.0 * M_PI); } }; // ============================================================================ // III. 44-BOND SYSTEM // ============================================================================ enum class BondType { INTRA_STRAND, // Bonds 1-16: within strand INTER_STRAND, // Bonds 17-32: between adjacent strands CROSS_HELIX // Bonds 33-44: across helix (|i-j| ∈ {4, 8, 12}) }; struct Bond { int id; // Bond number 1-44 BondType type; int strand_i; // First strand (1-16) int strand_j; // Second strand (1-16) double length; // Bond length in nm double angle; // Bond angle in radians double energy; // Bond energy double occupation; // Occupation state [0, 1] // Get bond position vector (midpoint) HelixPoint midpoint(double theta) const { auto p_i = G16Helix::point(strand_i, theta); auto p_j = G16Helix::point(strand_j, theta); return (p_i + p_j) * 0.5; } // Calculate bond length double calculate_length(double theta) const { auto p_i = G16Helix::point(strand_i, theta); auto p_j = G16Helix::point(strand_j, theta); return (p_i - p_j).norm(); } }; class BondSystem44 { private: std::array bonds_; std::array, NUM_STRANDS> adjacency_; public: BondSystem44() { initialize_bonds(); build_adjacency_matrix(); } // Initialize all 44 bonds according to distribution (Section 2.1) void initialize_bonds() { int bond_id = 0; // Intra-strand bonds (1-16): B_intra(k) = 1 for k = 1..16 for (int k = 1; k <= INTRA_STRAND_BONDS; ++k) { bonds_[bond_id++] = { bond_id, BondType::INTRA_STRAND, k, k, PITCH / NUM_STRANDS, // L₀ = P/16 = 0.225 nm M_PI, // 180° linear backbone 0.0, 1.0 }; } // Inter-strand bonds (17-32): B_inter(k, k+1 mod 16) = 1 for (int k = 1; k <= INTER_STRAND_BONDS; ++k) { int next_k = (k % NUM_STRANDS) + 1; bonds_[bond_id++] = { bond_id, BondType::INTER_STRAND, k, next_k, 2.0 * HELIX_RADIUS * std::sin(M_PI / BASE_PAIRS_PER_TURN), // d₀ = 0.59 nm STRAND_SEPARATION, // 22.5° 0.0, 1.0 }; } // Cross-helix bonds (33-44): pairs where |i-j| ∈ {4, 8, 12} // Pairs: (1,5), (2,6), (3,7), (4,8), (5,9), (6,10), // (7,11), (8,12), (9,13), (10,14), (11,15), (12,16) int cross_pairs[][2] = { {1,5}, {2,6}, {3,7}, {4,8}, {5,9}, {6,10}, {7,11}, {8,12}, {9,13}, {10,14}, {11,15}, {12,16} }; for (int m = 0; m < CROSS_HELIX_BONDS; ++m) { int i = cross_pairs[m][0]; int j = cross_pairs[m][1]; int diff = std::abs(i - j); double angle = diff * STRAND_SEPARATION; // |i-j| × 22.5° bonds_[bond_id++] = { bond_id, BondType::CROSS_HELIX, i, j, 0.0, // Calculated dynamically angle, 0.0, 1.0 }; } } // Build adjacency matrix (Section 2.4) void build_adjacency_matrix() { // Initialize to zero for (auto& row : adjacency_) { row.fill(0); } // Fill based on bonds for (const auto& bond : bonds_) { int i = bond.strand_i - 1; int j = bond.strand_j - 1; adjacency_[i][j] = 1; adjacency_[j][i] = 1; } } // Verify bond count: Σ_{i,j} A_{ij}/2 = 44 int verify_bond_count() const { int sum = 0; for (int i = 0; i < NUM_STRANDS; ++i) { for (int j = 0; j < NUM_STRANDS; ++j) { sum += adjacency_[i][j]; } } // Add intra-strand bonds (diagonal) sum += INTRA_STRAND_BONDS; return sum / 2 + INTRA_STRAND_BONDS; } // Get bond by type and index Bond& get_bond(int id) { return bonds_[id - 1]; } const Bond& get_bond(int id) const { return bonds_[id - 1]; } // Get bonds by type std::vector get_bonds_by_type(BondType type) const { std::vector result; for (const auto& bond : bonds_) { if (bond.type == type) { result.push_back(&bond); } } return result; } // Bond coordinate system (Section 2.2) std::pair bond_coordinates(int n) const { if (n <= INTRA_STRAND_BONDS) { // Intra-strand: (k, k) return {n, n}; } else if (n <= INTRA_STRAND_BONDS + INTER_STRAND_BONDS) { // Inter-strand: (k, k+1 mod 16) int k = n - INTRA_STRAND_BONDS; return {k, (k % NUM_STRANDS) + 1}; } else { // Cross-helix: (i, j) where |i-j| ∈ {4, 8, 12} return {bonds_[n-1].strand_i, bonds_[n-1].strand_j}; } } // 10.6-adjusted bond arc length: s_bond = 2πr/10.6 = 0.593 nm per bp static double bond_arc_length() { return 2.0 * M_PI * HELIX_RADIUS / BASE_PAIRS_PER_TURN; } // Vertical rise per bond: Δz_bond = P/44 = 0.0819 nm static double vertical_rise_per_bond() { return PITCH / TOTAL_BONDS; } // Adjacent bond length: L_adj = √[2r²(1 - cos(2π/10.6)) + h²] = 0.54 nm static double adjacent_bond_length() { double cos_term = 1.0 - std::cos(TWIST_ANGLE_RAD); return std::sqrt(2.0 * HELIX_RADIUS * HELIX_RADIUS * cos_term + RISE_PER_BP * RISE_PER_BP); } // Validation: distance constraint bool validate_distance(double epsilon_max) const { double adjustment = BASE_PAIRS_PER_TURN / 10.4; // 10.6/10.4 correction for (const auto& bond : bonds_) { if (bond.length > epsilon_max * adjustment) { return false; } } return true; } // Validation: angular constraint bool validate_angular(double delta_theta) const { for (const auto& bond : bonds_) { double target = std::round(bond.angle / TWIST_ANGLE_RAD) * TWIST_ANGLE_RAD; if (std::abs(bond.angle - target) > delta_theta) { return false; } } return true; } // Update all bond states void update_bonds(double theta) { for (auto& bond : bonds_) { bond.length = bond.calculate_length(theta); } } // Get total active bonds double total_occupation() const { double sum = 0.0; for (const auto& bond : bonds_) { sum += bond.occupation; } return sum; } }; // ============================================================================ // IV. STRAND MATHEMATICS // ============================================================================ // Fibonacci sequence generator inline uint64_t fibonacci(int n) { if (n <= 1) return n; uint64_t a = 0, b = 1; for (int i = 2; i <= n; ++i) { uint64_t c = a + b; a = b; b = c; } return b; } // Fibonacci-scaled strand: D_k = φ^k · F_k inline double fibonacci_scaled_strand(int k) { return std::pow(PHI, k) * fibonacci(k); } class StrandMathematics { private: std::array D_; // Fibonacci-scaled values std::array, NUM_STRANDS> S_; // Complex representation std::array, NUM_STRANDS> T_; // Transform public: StrandMathematics() { initialize(); } void initialize() { for (int k = 0; k < NUM_STRANDS; ++k) { D_[k] = fibonacci_scaled_strand(k + 1); } compute_transforms(); } // 16-strand helix sum: Helix₁₆ = Σ D_k·sin(kφ) double helix_sum_16() const { double sum = 0.0; for (int k = 1; k <= NUM_STRANDS; ++k) { sum += D_[k-1] * std::sin(k * PHI); } return sum; } // Bond formation: Bond_G16 = Π(1 + D_k/Helix₁₆) double bond_formation_g16() const { double helix = helix_sum_16(); double product = 1.0; for (int k = 0; k < NUM_STRANDS; ++k) { product *= (1.0 + D_[k] / helix); } return product; } // Crosslink function: Crosslink(i,j) = (D_i · D_j)/φ^{|i-j|} double crosslink(int i, int j) const { return (D_[i-1] * D_[j-1]) / std::pow(PHI, std::abs(i - j)); } // Complex strand representation: S_k = D_k · e^{ikφ} void compute_transforms() { for (int k = 0; k < NUM_STRANDS; ++k) { double phase = (k + 1) * PHI; S_[k] = D_[k] * std::exp(std::complex(0, phase)); // Transform: T_k = S_k · (cos(k) + i·sin(k)) double angle = k + 1; T_[k] = S_[k] * std::complex(std::cos(angle), std::sin(angle)); } } // Modular extraction: X_k = |T_k| mod φ^k double modular_extraction(int k) const { return std::fmod(std::abs(T_[k-1]), std::pow(PHI, k)); } // Fusion integral: Fusion = Σ(Strand_Vector(k) · φ⁻ᵏ) double fusion_integral() const { double sum = 0.0; for (int k = 0; k < NUM_STRANDS; ++k) { sum += std::abs(T_[k]) * std::pow(PHI_INV, k + 1); } return sum; } // Get D values double get_D(int k) const { return D_[k-1]; } std::complex get_S(int k) const { return S_[k-1]; } std::complex get_T(int k) const { return T_[k-1]; } }; // ============================================================================ // V. G¹⁶ TRANSFORMATION MATRICES // ============================================================================ struct Matrix3x3 { std::array, 3> m; Matrix3x3 operator*(const Matrix3x3& other) const { Matrix3x3 result = {{{0}}}; for (int i = 0; i < 3; ++i) { for (int j = 0; j < 3; ++j) { for (int k = 0; k < 3; ++k) { result.m[i][j] += m[i][k] * other.m[k][j]; } } } return result; } HelixPoint transform(const HelixPoint& p) const { return { m[0][0]*p.x + m[0][1]*p.y + m[0][2]*p.z, m[1][0]*p.x + m[1][1]*p.y + m[1][2]*p.z, m[2][0]*p.x + m[2][1]*p.y + m[2][2]*p.z }; } }; class G16Transform { public: // 22.5° increment rotation matrix (Section 5.1) static Matrix3x3 rotation_22_5(int k) { double angle = 2.0 * M_PI * k / NUM_STRANDS; double c = std::cos(angle); double s = std::sin(angle); return {{{ {c, -s, 0}, {s, c, 0}, {0, 0, 1} }}}; } // 10.6-adjusted rotation matrix static Matrix3x3 rotation_10_6(int k) { double angle = 2.0 * M_PI * k / BASE_PAIRS_PER_TURN; double c = std::cos(angle); double s = std::sin(angle); return {{{ {c, -s, 0}, {s, c, 0}, {0, 0, 1} }}}; } // Phase increment: Δφ = 2π/10.6 = 33.96° = 0.593 rad static double phase_increment() { return TWIST_ANGLE_RAD; } // Full G¹⁶ transform: G¹⁶ = Π R_k · T_k static Matrix3x3 full_transform() { Matrix3x3 result = {{{ {1, 0, 0}, {0, 1, 0}, {0, 0, 1} }}}; for (int k = 1; k <= NUM_STRANDS; ++k) { result = result * rotation_22_5(k); } return result; } // 10.6-adjusted full transform static Matrix3x3 full_transform_10_6() { Matrix3x3 result = {{{ {1, 0, 0}, {0, 1, 0}, {0, 0, 1} }}}; for (int k = 1; k <= NUM_STRANDS; ++k) { result = result * rotation_10_6(k); } return result; } }; // ============================================================================ // VI. 10.6 FIRING PATTERN // ============================================================================ class FiringPattern { public: // Phase calculation: phase(i,t) = ⌊(t + offset_i)/10.6⌋ mod 16 static int phase(int i, double t) { double offset = offset_distribution(i); return static_cast(std::floor((t + offset) / BASE_PAIRS_PER_TURN)) % NUM_STRANDS; } // Offset distribution: offset_i = i · φ⁻¹ · 10.6 static double offset_distribution(int i) { return i * PHI_INV * BASE_PAIRS_PER_TURN; } // Fire condition: fire(i,t) = [phase = 0] static bool should_fire(int i, double t) { return phase(i, t) == 0; } // Get all firing strands at time t static std::vector firing_strands(double t) { std::vector result; for (int i = 1; i <= NUM_STRANDS; ++i) { if (should_fire(i, t)) { result.push_back(i); } } return result; } // Synchronization period: T_sync = 10.6 × 16 = 169.6 static double sync_period() { return SYNC_PERIOD; } // Fundamental frequency: f₀ = 1/10.6 = 0.0943 static double fundamental_frequency() { return FUNDAMENTAL_FREQ; } // Harmonic: f_n = n/10.6 static double harmonic(int n) { return n / BASE_PAIRS_PER_TURN; } // 44-bond resonance: f_44 = 44/10.6 = 4.15 static double bond_resonance() { return BOND_RESONANCE_FREQ; } }; // ============================================================================ // VII. GOLDEN BASIS FUNCTIONS // ============================================================================ class GoldenBasis { public: // Basis function: ψ_k(x) = sin(2πφ^k · x) + cos(2πφ^k · x) static double psi(int k, double x) { double arg = 2.0 * M_PI * std::pow(PHI, k) * x; return std::sin(arg) + std::cos(arg); } // Generate basis vector for N terms static std::vector basis_vector(double x, int N) { std::vector result(N); for (int k = 0; k < N; ++k) { result[k] = psi(k, x); } return result; } // Global coherence: Φ_total = (1/N) Σ Φ_i // where Φ_i = 1/(1 + |x_i - 1|) static double global_coherence(const std::vector& x) { double sum = 0.0; for (double xi : x) { sum += 1.0 / (1.0 + std::abs(xi - 1.0)); } return sum / x.size(); } // Ring diffusion: dS_i/dt = λ(S_{i+1} + S_{i-1} - 2S_i) static void ring_diffusion_step(std::vector& S, double lambda, double dt) { int N = S.size(); std::vector dS(N); for (int i = 0; i < N; ++i) { int prev = (i - 1 + N) % N; int next = (i + 1) % N; dS[i] = lambda * (S[next] + S[prev] - 2.0 * S[i]); } for (int i = 0; i < N; ++i) { S[i] += dS[i] * dt; } } }; // ============================================================================ // VIII. SUPERCOILING (10.6) // ============================================================================ class Supercoiling { public: // Linking number: Lk = Tw + Wr static double linking_number(double twist, double writhe) { return twist + writhe; } // Twist for 16 strands: Tw = N/10.6 × 16 static double twist_16_strands(int N) { return (static_cast(N) / BASE_PAIRS_PER_TURN) * NUM_STRANDS; } // Relaxed linking number: Lk₀ = N/10.6 static double relaxed_linking_number(int N) { return static_cast(N) / BASE_PAIRS_PER_TURN; } // Superhelical density: σ = (Lk - Lk₀)/Lk₀ static double superhelical_density(double Lk, double Lk0) { return (Lk - Lk0) / Lk0; } // G¹⁶ superhelical density static double superhelical_density_g16(double Lk, int N) { double Lk0_g16 = NUM_STRANDS * static_cast(N) / BASE_PAIRS_PER_TURN; return (Lk - Lk0_g16) / Lk0_g16; } // Free energy of supercoiling // ΔG_sc = K · N · σ² · (10.6/10.4)² static double free_energy(double K, int N, double sigma) { constexpr double correction = (BASE_PAIRS_PER_TURN / 10.4) * (BASE_PAIRS_PER_TURN / 10.4); return K * N * sigma * sigma * correction; } // G¹⁶ with 44-bond correction static double free_energy_g16(double K, int N, double sigma_g16, double lambda) { constexpr double correction = (BASE_PAIRS_PER_TURN / 10.4) * (BASE_PAIRS_PER_TURN / 10.4); return K * N * sigma_g16 * sigma_g16 * (1.0 + lambda * TOTAL_BONDS) * correction; } }; // ============================================================================ // COMPLETE G¹⁶ HELIX SYSTEM // ============================================================================ class G16HelixSystem { private: G16Helix helix_; BondSystem44 bonds_; StrandMathematics strands_; double time_; double global_phase_; // φ_10.6(t) // State vectors std::array, NUM_STRANDS> strand_states_; std::array angular_positions_; public: G16HelixSystem() : time_(0.0), global_phase_(0.0) { initialize(); } void initialize() { // Initialize strand states: S_k(t=0) = A_k · e^{i(2πk/10.6)} for (int k = 0; k < NUM_STRANDS; ++k) { double amplitude = strands_.get_D(k + 1); double phase = 2.0 * M_PI * (k + 1) / BASE_PAIRS_PER_TURN; strand_states_[k] = amplitude * std::exp(std::complex(0, phase)); angular_positions_[k] = phase; } } // Tick the system forward void tick(double dt) { time_ += dt; // Update global phase: φ(t) = (2πt/10.6) mod 2π global_phase_ = std::fmod(2.0 * M_PI * time_ / BASE_PAIRS_PER_TURN, 2.0 * M_PI); // Update strand states: S_k(t) = A_k · e^{i(ωt + 2πk/10.6)} for (int k = 0; k < NUM_STRANDS; ++k) { double amplitude = strands_.get_D(k + 1); double phase = ANGULAR_FREQUENCY * time_ + 2.0 * M_PI * (k + 1) / BASE_PAIRS_PER_TURN; strand_states_[k] = amplitude * std::exp(std::complex(0, phase)); angular_positions_[k] = phase; } // Update bond states bonds_.update_bonds(global_phase_); } // Get firing strands std::vector get_firing_strands() const { return FiringPattern::firing_strands(time_); } // Get global coherence double get_coherence() const { std::vector magnitudes(NUM_STRANDS); for (int k = 0; k < NUM_STRANDS; ++k) { magnitudes[k] = std::abs(strand_states_[k]); } return GoldenBasis::global_coherence(magnitudes); } // Get total bond occupation double get_bond_occupation() const { return bonds_.total_occupation(); } // Accessors double time() const { return time_; } double global_phase() const { return global_phase_; } const BondSystem44& bonds() const { return bonds_; } BondSystem44& bonds() { return bonds_; } const StrandMathematics& strands() const { return strands_; } }; } // namespace agi::dna