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For nonnegative magnesium concentration, the denominator is at least one and the factor lies between zero and one. Increasing voltage reduces the exponential term and increases the unblocked fraction. The coefficients assume the voltage and concentration units stated in the source.
Terms & definitions
| Term | Meaning in this source |
|---|---|
| B | Unblocked conductance fraction |
| V | Voltage in millivolts |
| Mg_o | External magnesium concentration in millimolar |
How it works
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Assumptions & limits
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Original context
Read the surrounding source passage
void step(float dt) {
s *= std::exp(-dt / tau);
}
};
// NMDA Receptor (slow excitatory, voltage-dependent Mg2+ block)
// I_NMDA = g_NMDA * s * B(V) * (V - E_NMDA)
// B(V) = 1 / (1 + [Mg2+]_o * exp(-0.062*V) / 3.57)
struct NMDASynapse {
float g_max = 0.5f; // nS
float E_rev = 0.0f; // mV
float tau_rise = 2.0f; // ms
float tau_decay = 100.0f;// ms - NMDA is slow!
float Mg_o = 1.0f; // mM - External Mg2+ concentration
float s = 0.0f;
float x = 0.0f; // Rise variable
// Mg2+ block factorExact original notation
B(V) = 1 / (1 + [Mg2+]_o * exp(-0.062*V) / 3.57)